9800gx2

either bad secter on HDD or that file is crashing at that time.

if bad secter, u need to check ur brand of HDD. (for exampl, segate brand. they have a software tools to fix all bad secter on thier branded HDD)

If  it is crashing at that time. normally restart the OS will solve.

Or if that file not in c drive where the window installed. then u can just format that partition .

But is there any reason u must delete it? i don't think it will be harm to have that file in it.